Folic Acid from Fortified Foods and/or Supplements during Pregnancy and Lactation and Health Outcomes: A Systematic Review [Internet]

Review

Alexandria (VA): USDA Nutrition Evidence Systematic Review; 2020 Jul.

¹ Chair, Pregnancy and Lactation Subcommittee, 2020 Dietary Guidelines Advisory Committee; University of Illinois, Urbana-Champaign
² Member, Pregnancy and Lactation Subcommittee, 2020 Dietary Guidelines Advisory Committee; University of California, Davis
³ Member, Pregnancy and Lactation Subcommittee, 2020 Dietary Guidelines Advisory Committee; University of Hawaii
⁴ Member, Pregnancy and Lactation Subcommittee, 2020 Dietary Guidelines Advisory Committee; University of Minnesota
⁵ Member, Pregnancy and Lactation Subcommittee, 2020 Dietary Guidelines Advisory Committee; Massachusetts General Hospital, Harvard Medical School, and Harvard T.H. Chan School of Public Health
⁶ Vice-Chair, 2020 Dietary Guidelines Advisory Committee; Massachusetts General Hospital, Harvard Medical School
⁷ Systematic review analyst, Nutrition Evidence Systematic Review (NESR) team; Panum Group under contract with the Food and Nutrition Service (FNS), U.S. Department of Agriculture (USDA)
⁸ Biomedical librarian, NESR team; National Institutes of Health Library, U.S. Department of Health and Human Services
⁹ Systematic review librarian, NESR team; Panum Group under contract with the FNS, USDA
¹⁰ Project Lead, NESR team; Nutrition Guidance and Analysis Division, Center for Nutrition Policy and Promotion, FNS, USDA

Excerpt

The goal of this systematic review was to examine the following questions:

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What is the relationship between folic acid from supplements and/or fortified foods consumed before and during pregnancy and lactation and micronutrient status?
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What is the relationship between folic acid from supplements and/or fortified foods consumed before and during pregnancy and risk of gestational diabetes?
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What is the relationship between folic acid from supplements and/or fortified foods consumed before and during pregnancy and risk of hypertensive disorders during pregnancy?
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What is the relationship between folic acid from supplements and/or fortified foods consumed before and during pregnancy and lactation and human milk composition?
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What is the relationship between folic acid from supplements and/or fortified foods consumed before and during pregnancy and lactation and developmental milestones, including neurocognitive development, in the child?

FUNDING SOURCE: United States Department of Agriculture, Food and Nutrition Service, Center for Nutrition Policy and Promotion, Alexandria, VA