Efficacy of concentrated growth factor with low-level laser for the regeneration of interdental papilla defects

Odontology. 2022 Oct;110(4):795-804. doi: 10.1007/s10266-022-00702-y. Epub 2022 Mar 15.


Gingival "black triangle" is common in clinical which due to interdental papilla recession. The cause of the loss of papilla is multi-factorial and it may be caused by the absorption of interdental alveolar bone or abnormal tooth position. Besides, it is a common complication after orthodontics and implant surgery. Recession of gingival papilla influences interdental plaque control, increasing food impaction and alveolar bone absorption, causing aesthetic and pronunciation problems. Thus, the way of reducing or eliminating the gingival "black triangle" has become one of the most essential problems for dentists. Concentrated growth factor (CGF) and low-level-laser therapy have been widely used, respectively, and CGF was considered as the only self-substance which has soft tissue regeneration function. This study aims to evaluate the efficacy of regenerating interdental papilla by Liquid phase concentrated growth factor (LPCGF) injection with low-level-laser therapy (LLLT).

Keywords: Gingival black triangle; Gingival papilla; Liquid phase concentrated growth factor; Low-level-laser therapy; Photobiomodulation therapy.

MeSH terms

  • Gingiva*
  • Intercellular Signaling Peptides and Proteins
  • Lasers*
  • Light


  • Intercellular Signaling Peptides and Proteins