The P132H mutation in the main protease of Omicron SARS-CoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition
Cell Res. 2022 May;32(5):498-500.
doi: 10.1038/s41422-022-00640-y.
Epub 2022 Mar 15.
1 Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
2 Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, USA.
3 Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC, USA.
4 Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN, USA.
5 Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, NJ, USA. junwang@pharmacy.rutgers.edu.
6 Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. ychen1@usf.edu.