Adipocyte-specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction

FEBS Lett. 2022 Jun;596(11):1434-1444. doi: 10.1002/1873-3468.14335. Epub 2022 Mar 30.

Abstract

Adipose tissue regulates whole-body energy homeostasis. Both lipodystrophy and obesity, the extreme and opposite aspects of adipose tissue dysfunction, result in metabolic disorders: insulin resistance and hepatic steatosis. Cyclin-dependent kinases (CDKs) have been reported to be involved in adipose tissue development and functions. Using adipose tissue-specific knockout mice, here we demonstrate that the deletion of CDK7 in adipose tissue results in progressive lipodystrophy, insulin resistance, impaired adipokine secretion and downregulation of fat-specific genes, which are aggravated on high-fat diet and during ageing. Our studies suggest that CDK7 is a key regulatory component of adipose tissue maintenance and systemic energy homeostasis.

Keywords: adipose tissue; cyclin-dependent kinase 7; lipid metabolism; lipodystrophy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipocytes / metabolism
  • Adipose Tissue / metabolism
  • Animals
  • Diet, High-Fat / adverse effects
  • Energy Metabolism / genetics
  • Insulin Resistance* / genetics
  • Lipodystrophy* / metabolism
  • Mice
  • Mice, Knockout