Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 79 (9), 1089-93

Klinefelter's Syndrome: Historical Background and Development

  • PMID: 3529433

Klinefelter's Syndrome: Historical Background and Development

H F Klinefelter. South Med J.


When described more than 40 years ago, Klinefelter's syndrome (small testes, sterility, increased excretion of follicle-stimulating hormone, and usually gynecomastia) was thought to be an endocrine disorder. A second testicular hormone was postulated but has never been isolated. During the ensuing years, the syndrome has been found to be a chromosomal disorder, in which there is an extra X chromosome in 80% of the patients. The disorder occurs once in 500 to 1,000 male births and is best diagnosed by a buccal smear. When there is androgen deficiency, it is treated with testosterone. Gynecomastia is treated surgically because of the potential danger of malignancy or for cosmetic reasons.

Similar articles

See all similar articles

Cited by 5 PubMed Central articles

Publication types

LinkOut - more resources