Zebrafish Behavioral Assays in Toxicology

Methods Mol Biol. 2022;2474:109-122. doi: 10.1007/978-1-0716-2213-1_11.


Zebrafish behavioral assays are commonly used to identify and study environmental stressors that elicit adverse effects on neurobehavior. Behavioral assay platforms are available for multiple life stages (embryonic, juvenile, and adults) and are robust in detecting stressor-induced acute effects on neurodevelopment as well as long term deficits in sensory mechanisms, social behavior, learning, memory, and neurodegenerative diseases. Within this chapter, we present an overview of zebrafish behavioral assays that are commonly used to study environmental neurotoxicants.

Keywords: Behavior; Learning and memory; Neurotoxicants; Photomotor response; Social behavior; Zebrafish.

Publication types

  • Review

MeSH terms

  • Animals
  • Learning
  • Social Behavior*
  • Zebrafish*