A double blind study with melperone and placebo in the treatment of chronic alcoholics

Int J Clin Pharmacol Biopharm. 1978 Jul;16(7):331-2.


In a 2-wk randomized double blind study 60 chronic alcoholics were treated with either melperone (Buronil) or placebo. The patients were assessed daily using a scale including 4 items: tension, depression, craving and sleep. Statistically significant improvement was achieved in the placebo group only for "tension" and "sleep"; whereas, in the melperone group all four items improved significantly. Comparison between the groups revealed statistically significant superiority of melperone over placebo for the item "craving".

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Alcoholism / drug therapy*
  • Butyrophenones / therapeutic use*
  • Clinical Trials as Topic
  • Depression / drug therapy
  • Double-Blind Method
  • Humans
  • Male
  • Middle Aged
  • Piperidines / therapeutic use
  • Placebos
  • Sleep
  • Surveys and Questionnaires


  • Butyrophenones
  • Piperidines
  • Placebos
  • metylperon