Interneurons direct circuit-specific flow of information to communicate stressful experiences

Kirstie Cummings; Jamie Maguire

doi:10.1016/j.neuron.2022.02.019

Interneurons direct circuit-specific flow of information to communicate stressful experiences

Neuron. 2022 Mar 16;110(6):911-913. doi: 10.1016/j.neuron.2022.02.019.

Authors

Kirstie Cummings¹, Jamie Maguire²

Affiliations

¹ Department of Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, 1825 University Blvd., Birmingham, AL 35233, USA.
² Neuroscience Department, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111, USA. Electronic address: jamie.maguire@tufts.edu.

PMID: 35298916
DOI: 10.1016/j.neuron.2022.02.019

Abstract

The prefrontal cortex coordinates experience-dependent alterations in behavioral states. In this issue of Neuron, Joffe et al. provide a novel mechanism mediating acute stress-induced biasing of information routing through the mPFC, involving mGlu5-mediated plasticity on SST interneurons and feedforward inhibition shaping input into the mPFC.

Interneurons direct circuit-specific flow of information to communicate stressful experiences

Authors

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Abstract

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