In a study of visual prognosis after repeat penetrating keratoplasty, we found that 18 of 29 eyes required only one regraft and 11 required multiple repeat penetrating keratoplasties. After an average follow-up of 15.7 months, six of the 18 eyes with only one regraft had achieved visual acuities of 20/100 or better. After an average follow-up of 27.5 months, only one of 11 eyes with multiple regrafts achieved a best corrected visual acuity of 20/100 or better.