The role of hyperinsulinaemia in screening for prediabetes in the adolescent population: A systematic literature review

Prudence Stevens; Jennifer Hunter; Eugen Molodysky

doi:10.1016/j.dsx.2022.102445

The role of hyperinsulinaemia in screening for prediabetes in the adolescent population: A systematic literature review

Diabetes Metab Syndr. 2022 Apr;16(4):102445. doi: 10.1016/j.dsx.2022.102445. Epub 2022 Mar 8.

Authors

Prudence Stevens¹, Jennifer Hunter², Eugen Molodysky³

Affiliations

¹ Sydney Medical School, University of Sydney, Australia.
² Health Research Group, Sydney, Australia.
³ Sydney Medical School, University of Sydney, Australia. Electronic address: molodysky@ozemail.com.au.

PMID: 35305511
DOI: 10.1016/j.dsx.2022.102445

Abstract

Background/aims: Present screening methods for Type 2 diabetes (T2DM) fall short of detecting prediabetes. This paper summarises the literature on the utility of insulin measurements (hyperinsulinemia) in detecting prediabetes in adolescents.

Methods: A systematic literature review was conducted using EMBASE and Medline. Relevant data on hyperinsulinemia in the adolescent population is narrated.

Results: The database search identified 174 potential articles; 106 underwent a full-paper review, and 36 were included.

Conclusion: Elevated fasting insulin is a marker of impaired insulin resistance and pending beta-cell dysfunction in at-risk adolescents and can be an early indicator of prediabetes.

Keywords: Adolescence; Early diabetes; Elevated insulin; Hyperinsulinemia; Metabolic syndrome; Prediabetes; Type 2 diabetes.

Publication types

Systematic Review

MeSH terms

Adolescent
Diabetes Mellitus, Type 2* / diagnosis
Diabetes Mellitus, Type 2* / epidemiology
Fasting
Humans
Insulin Resistance*
Insulins*
Prediabetic State* / diagnosis
Prediabetic State* / epidemiology

Substances

Insulins