Elevated serum fibrinogen/albumin ratios in patients with acute central serous chorioretinopathy

Eur J Ophthalmol. 2022 May;32(3):1735-1742. doi: 10.1177/11206721221089773. Epub 2022 Mar 21.


Purpose: To evaluate the serum fibrinogen/albumin ratios in patients with acute and chronic central serous chorioretinopathy, and healthy control samples.

Methods: Serum fibrinogen/albumin ratios were assessed in patients with acute (Group-1, 30 eyes) and chronic (Group-2, 30 eyes) central serous chorioretinopathy, and compared with healthy control (Group-3, 30 eyes) samples.

Results: Fibrinogen/albumin ratios were significantly higher in Group-1 (104.72 ± 12.34) than in Group-2 (75.83 ± 10.06) and in Group-3 (72 ± 9.54) (p = 0.001). No significant correlation was found between age, CMT, and BCVA with fibrinogen/albumin ratios in the Pearson correlation analysis. In the ROC curve analysis, the most appropriate cut-off value of the fibrinogen/albumin ratio for acute CSCR was ≥87.8 and the optimal cut-off value for the fibrinogen/albumin ratio for chronic CSCR was ≥68.6.

Conclusion: The fibrinogen/albumin ratio may be useful as an inflammatory biomarker to monitor the systemic inflammatory state during the treatment and follow-up in patients with acute CSCR.

Keywords: acute central serous chorioretinopathy; chronic central serous chorioretinopathy; serum fibrinogen/albumin ratios; serum inflammatory markers; systemic inflammatory state.

MeSH terms

  • Acute Disease
  • Albumins
  • Central Serous Chorioretinopathy* / diagnosis
  • Fibrinogen
  • Fluorescein Angiography
  • Humans
  • Retrospective Studies
  • Tomography, Optical Coherence
  • Visual Acuity


  • Albumins
  • Fibrinogen