[Pharmacokinetic profiles of antifungal drugs during extracorporeal membrane oxygenation life support]

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2022 Jan;34(1):100-104. doi: 10.3760/cma.j.cn121430-20210816-01186.
[Article in Chinese]


Extracorporeal membrane oxygenation (ECMO), a kind of life support technology that can replace lung and heart function, is widely used in critical respiratory and circulatory exhaustion. Because of the serious diseases and the use of interventional catheters, patients receiving ECMO life support are often administrated with broad-spectrum antimicrobial agents, which increase the risk of fungal infection. Fungal infection during ECMO can increase mortality. How to effectively control fungal infection is a thorny problem faced by clinicians. During the treatment of ECMO, the patient's physiological status, ECMO oxygenation membrane, circulation pipeline and other factors may change the pharmacokinetic profiles of antifungal drugs, thereby affect the clinical efficacy of drugs. This artical reviews the pharmacokinetic characteristics of antifungal drugs during ECMO support, in order to provide references for clinical antifungal treatment.

MeSH terms

  • Antifungal Agents / therapeutic use
  • Extracorporeal Membrane Oxygenation*
  • Humans
  • Mycoses*
  • Treatment Outcome


  • Antifungal Agents