Streptococcus mutans and Candida albicans Biofilm Inhibitors Produced by Lactiplantibacillus plantarum CCFM8724

Jiaxun Li; Qiuxiang Zhang; Jianxin Zhao; Hao Zhang; Wei Chen

doi:10.1007/s00284-022-02833-5

Streptococcus mutans and Candida albicans Biofilm Inhibitors Produced by Lactiplantibacillus plantarum CCFM8724

Curr Microbiol. 2022 Mar 24;79(5):143. doi: 10.1007/s00284-022-02833-5.

Authors

Jiaxun Li^{1

2}, Qiuxiang Zhang^{3

4

5}, Jianxin Zhao^{1

2}, Hao Zhang^{1

2

6}, Wei Chen^{1

2

6}

Affiliations

¹ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
² School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
³ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China. zhangqx@jiangnan.edu.cn.
⁴ School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China. zhangqx@jiangnan.edu.cn.
⁵ (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou, 225004, China. zhangqx@jiangnan.edu.cn.
⁶ National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, 214122, Jiangsu, China.

PMID: 35325333
DOI: 10.1007/s00284-022-02833-5

Abstract

Lactiplantibacillus plantarum CCFM8724 inhibits the growth of Streptococcus mutans and Candida albicans in mixed-species biofilm formation. In this study, bioactive compound including cyclo (leu-pro), cyclo (phe-pro), and some organic acids, such as 3-phenyllactic acid, hydrocinnamic acid, and palmitic acid, were identified through GC-MS analysis. At 50 μg·mL^-1, cyclo (leu-pro) reduced biofilm mass (OD₆₀₀) from 3.00 to 2.00, and hydrocinnamic acid at 25 μg·mL^-1 reduced biofilm mass (OD₆₀₀) from 3.00 to 1.00. The expression of ALS3 and HWP1 was downregulated by cyclo (leu-pro). Furthermore, a mixture of cyclo (leu-pro), cyclo (phe-pro), 3-phenyllactic acid, hydrocinnamic acid, and palmitic acid, had anti-biofilm activity. Overall, the results provide promising baseline information for the potential use of this probiotic and its components in preventing biofilm formation.

MeSH terms

Biofilms
Candida albicans
Probiotics*
Streptococcus mutans*

Abstract

MeSH terms

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