The susceptibility of Cryptococcus neoformans to an antimycotic agent (G2) from alfalfa

Zentralbl Bakteriol Mikrobiol Hyg A. 1986 Jul;261(4):481-6. doi: 10.1016/s0176-6724(86)80080-3.

Abstract

Compound G2, 2-beta-hydroxy-3-beta-O-(beta-D-glucopyranosyl)-delta 12-oleanene-23,28-dionic acid, isolated from alfalfa roots, demonstrated considerable activity against Cryptococcus neoformans (MIC value of 2 micrograms/ml). Compound G2 exhibited rapid killing of this fungus (MFC value of 4 micrograms/ml) suggesting that it might be a useful active agent in the treatment of cryptococcosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Cryptococcus / drug effects*
  • Cryptococcus neoformans / drug effects*
  • Kinetics
  • Medicago sativa*
  • Plant Extracts / pharmacology
  • Saponins / pharmacology*
  • Triterpenes / pharmacology*

Substances

  • Antifungal Agents
  • Plant Extracts
  • Saponins
  • Triterpenes
  • medicagenic acid-3-O-glucopyranoside