Virucidal Activity of Different Mouthwashes against the Salivary Load of SARS-CoV-2: A Narrative Review

Healthcare (Basel). 2022 Mar 3;10(3):469. doi: 10.3390/healthcare10030469.


The saliva of COVID-19-confirmed patients presents a high viral load of the virus. Aerosols generated during medical and dental procedures can transport the virus and are a possible causative agent of cross-infection. Since the onset of the pandemic, numerous investigations have been attempting to mitigate the risk of transmission by reducing the viral load in saliva using preprocedural mouthwashes. This study aims to review the most up-to-date in vitro and in vivo studies investigating the efficacy of different mouthwashes on reducing the salivary viral load of SARS-CoV-2, giving particular attention to the most recent randomized control trials published.

Keywords: COVID-19; SARS-CoV-2; aerosols; cetylpyridinium chloride; chlorhexidine; colony-forming units; hydrogen peroxide; mouthwashes; povidone-iodine.

Publication types

  • Review