Roles of Cullin-RING Ubiquitin Ligases in Cardiovascular Diseases

Biomolecules. 2022 Mar 8;12(3):416. doi: 10.3390/biom12030416.


Maintenance of protein homeostasis is crucial for virtually every aspect of eukaryotic biology. The ubiquitin-proteasome system (UPS) represents a highly regulated quality control machinery that protects cells from a variety of stress conditions as well as toxic proteins. A large body of evidence has shown that UPS dysfunction contributes to the pathogenesis of cardiovascular diseases. This review highlights the latest findings regarding the physiological and pathological roles of cullin-RING ubiquitin ligases (CRLs), an essential player in the UPS, in the cardiovascular system. To inspire potential therapeutic invention, factors regulating CRL activities are also discussed.

Keywords: cardiovascular disease; cullin-RING ligases; protein degradation; protein ubiquitination; ubiquitin E3 ligases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cardiovascular Diseases*
  • Cullin Proteins / metabolism
  • Humans
  • Proteasome Endopeptidase Complex / metabolism
  • Ubiquitin* / metabolism
  • Ubiquitin-Protein Ligases / metabolism
  • Ubiquitination


  • Cullin Proteins
  • Ubiquitin
  • Ubiquitin-Protein Ligases
  • Proteasome Endopeptidase Complex