Is COL1A1 Gene rs1107946 Polymorphism Associated with Sport Climbing Status and Flexibility?

Genes (Basel). 2022 Feb 23;13(3):403. doi: 10.3390/genes13030403.


The purpose of this study was to compare the frequency of COL1A1 rs1107946 polymorphism between sport climbers and controls from three ethnic groups (Japanese, Polish, and Russian) and investigate the effect of the COL1A1 rs1107946 polymorphism on the age-related decrease in flexibility in the general population. Study I consisted of 1929 healthy people (controls) and 218 climbers, including Japanese, Polish, and Russian participants. The results of the meta-analysis showed that the frequency of the AC genotype was higher in climbers than in the controls (p = 0.03). Study II involved 1093 healthy Japanese individuals (435 men and 658 women). Flexibility was assessed using a sit-and-reach test. There was a tendency towards association between sit-and-reach and the COL1A1 rs1107946 polymorphism (genotype: p = 0.034; dominant: p = 0.435; recessive: p = 0.035; over-dominant: p = 0.026). In addition, there was a higher negative correlation between sit-and-reach and age in the AA + CC genotype than in the AC genotype (AA + CC: r = −0.216, p < 0.001; AC: r = −0.089, p = 0.04; interaction p = 0.037). However, none of these results survived correction for multiple testing. Further studies are warranted to investigate the association between the COL1A1 gene variation and exercise-related phenotypes.

Keywords: COL1A1; aging; flexibility; genotype; heterozygosity; polymorphism; sit-and-reach; sports climbing.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Collagen Type I, alpha 1 Chain / genetics*
  • Female
  • Genotype
  • Humans
  • Male
  • Polymorphism, Genetic*
  • Russia
  • Sports*


  • COL1A1 protein, human
  • Collagen Type I, alpha 1 Chain