Is hypoimmunogenic stem cell therapy safe in times of pandemics?

Stem Cell Reports. 2022 Apr 12;17(4):711-714. doi: 10.1016/j.stemcr.2022.02.014. Epub 2022 Mar 24.


The manipulation of human leukocyte antigens (HLAs) and immune modulatory factors in "universal" human pluripotent stem cells (PSCs) holds promise for immunological tolerance without HLA matching. This paradigm raises concerns should "universal" grafts become virally infected. Furthermore, immunological manipulation might functionally impair certain progeny, such as hematopoietic stem cells. We discuss the risks and benefits of hypoimmunogenic PSCs, and the need to further advance HLA matching and autologous strategies.

Publication types

  • Review

MeSH terms

  • HLA Antigens
  • Humans
  • Pandemics*
  • Pluripotent Stem Cells*
  • Stem Cell Transplantation / adverse effects


  • HLA Antigens