Copper-Free Halodediazoniation of Arenediazonium Tetrafluoroborates in Deep Eutectic Solvents-like Mixtures

Molecules. 2022 Mar 15;27(6):1909. doi: 10.3390/molecules27061909.

Abstract

Deep Eutectic Solvent (DES)-like mixtures, based on glycerol and different halide organic and inorganic salts, are successfully exploited as new media in copper-free halodediazoniation of arenediazonium salts. The reactions are carried out in absence of metal-based catalysts, at room temperature and in a short time. Pure target products are obtained without the need for chromatographic separation. The solvents are fully characterized, and a computational study is presented aiming to understand the reaction mechanism.

Keywords: Sandmeyer reactions; deep eutectic solvents; reaction mechanism.

MeSH terms

  • Catalysis
  • Deep Eutectic Solvents*
  • Glycerol*
  • Solvents / chemistry

Substances

  • Deep Eutectic Solvents
  • Solvents
  • Glycerol