[Mutants of Saccharomyces cerevisiae supersensitive to the mutagenic effect of 6-N-hydroxylaminopurine]

Genetika. 1986 Sep;22(9):2235-43.
[Article in Russian]


Yeast mutants hypersensitive to the mutagenic action of 6-N-hydroxylaminopurine (HAP) were obtained by EMS mutagenesis. One of the mutants segregated monogenically and possessed reduced capacity to utilize HAP as a purine source. A set of diploids suitable for parallel study of mutagenesis and induction of recombination, and differing in the trait of mutability after exposure to HAP ("hm" trait or HAP mutability), were constructed. It was shown that a weak recombinogenic effect of HAP is not enhanced in "hm" mutants when HAP mutability increases.

MeSH terms

  • Adenine / analogs & derivatives*
  • Adenine / toxicity
  • Alleles
  • Drug Resistance, Microbial
  • Genes, Fungal
  • Mutagens*
  • Mutation*
  • Recombination, Genetic
  • Saccharomyces cerevisiae / genetics*


  • Mutagens
  • 6-N-hydroxylaminopurine
  • Adenine