New therapy strategies in the management of breast cancer

Sevgi Yardim-Akaydin; Bensu Karahalil; Sultan Nacak Baytas

doi:10.1016/j.drudis.2022.03.014

New therapy strategies in the management of breast cancer

Drug Discov Today. 2022 Jun;27(6):1755-1762. doi: 10.1016/j.drudis.2022.03.014. Epub 2022 Mar 22.

Authors

Sevgi Yardim-Akaydin¹, Bensu Karahalil², Sultan Nacak Baytas³

Affiliations

¹ Department of Biochemistry, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey.
² Department of Toxicology, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey.
³ Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey. Electronic address: baytas@gazi.edu.tr.

PMID: 35337961
DOI: 10.1016/j.drudis.2022.03.014

Abstract

Breast cancer (BC), the second leading cause of cancer-related deaths after lung cancer, is the most common cancer type among women worldwide. BC comprises multiple subtypes based on molecular properties. Depending on the type of BC, hormone therapy, targeted therapy, and immunotherapy are the current systemic treatment options along with conventional chemotherapy. Several new molecular targets, miRNAs, and long non-coding RNAs (lncRNAs), have been discovered over the past few decades and are powerful potential therapeutic targets. Here, we review advanced therapeutics as new players in BC management.

Keywords: Breast cancer; HOTAIR; MALATI; Therapy strategies; lncRNA; miRNAs.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Breast Neoplasms* / drug therapy
Female
Humans
MicroRNAs*
RNA, Long Noncoding*

Substances

MicroRNAs
RNA, Long Noncoding