The role of antigen-presenting cells in the pathogenesis of COVID-19

Rana Farzi; Parisa Shiri Aghbash; Narges Eslami; Arezou Azadi; Ali Shamekh; Nima Hemmat; Taher Entezari-Maleki; Hossein Bannazadeh Baghi

doi:10.1016/j.prp.2022.153848

The role of antigen-presenting cells in the pathogenesis of COVID-19

Pathol Res Pract. 2022 May:233:153848. doi: 10.1016/j.prp.2022.153848. Epub 2022 Mar 23.

Authors

Rana Farzi¹, Parisa Shiri Aghbash¹, Narges Eslami², Arezou Azadi³, Ali Shamekh⁴, Nima Hemmat⁵, Taher Entezari-Maleki⁶, Hossein Bannazadeh Baghi⁷

Affiliations

¹ Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
² Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
³ Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
⁴ Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
⁵ Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Drug Applied Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
⁶ Department of Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
⁷ Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: hbannazadeh@tbzmed.ac.ir.

Abstract

Coronavirus Disease 2019 (COVID-19) is one of the three lethal coronavirus outbreaks in the recent two decades and a serious threat to global health all over the world. The principal feature of the COVID-19 infection is the so-called "cytokine storm" exaggerated molecular response to virus distribution, which plays massive tissue and organ injury roles. Immunological treatments, including monoclonal antibodies and vaccines, have been suggested as the main approaches in treating and preventing this disease. Therefore, a proper investigation of the roles of antigen-presenting cells (APCs) in the aforementioned immunological responses appears essential. The present review will provide detailed information about APCs' role in the infection and pathogenesis of SARS-CoV-2 and the effect of monoclonal antibodies in diagnosis and treatment.

Keywords: Antigen Presenting Cell; B cells; COVID-19; DC; Macrophages; SARS-CoV-2.

Publication types

Review

MeSH terms

Antibodies, Monoclonal
Antigen-Presenting Cells
COVID-19*
Humans
SARS-CoV-2

Substances

Antibodies, Monoclonal