Expression analysis of IFNAR1 and TYK2 transcripts in COVID-19 patients

Cytokine. 2022 May:153:155849. doi: 10.1016/j.cyto.2022.155849. Epub 2022 Mar 4.


As a member of JAK family of non-receptor tyrosine kinases, TYK2 has a crucial role in regulation of immune responses. This protein has a crucial role in constant expression of IFNAR1 on surface of cells and initiation of type I IFN signaling. In the current study, we measured expression of IFNAR1 and TYK2 levels in venous blood samples of COVID-19 patients and matched controls. TYK2 was significantly down-regulated in male patients compared with male controls (RME = 0.34, P value = 0.03). Though, levels of TYK2 were not different between female cases and female controls, or between ICU-admitted and non-ICU-admitted cases. Expression of IFNAR1 was not different either between COVID-19 cases and controls or between patients required ICU admission and non-ICU-admitted cases. However, none of these transcripts can properly diffrentiate COVID-19 cases from controls or separate patients based on disease severity. The current study proposes down-regulation of TYK2 as a molecular mechanism for incapacity of SARS-CoV-2 in induction of a competent IFN response.

Keywords: Biomarker; COVID-19; Expression; IFNAR1; TYK2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19*
  • Female
  • Humans
  • Male
  • Proteins / metabolism
  • Receptor, Interferon alpha-beta / genetics
  • Receptor, Interferon alpha-beta / metabolism
  • SARS-CoV-2
  • TYK2 Kinase / genetics
  • TYK2 Kinase / metabolism


  • IFNAR1 protein, human
  • Proteins
  • Receptor, Interferon alpha-beta
  • TYK2 Kinase
  • TYK2 protein, human