Genetic, environmental and life-style factors associated with longevity. Protocol and response of the LONGECYL Study

Gac Sanit. 2022 May-Jun;36(3):260-264. doi: 10.1016/j.gaceta.2022.01.005. Epub 2022 Mar 23.


Objective: To describe the objectives, the methodological approach, the response rate of the Genetic, Environmental and Life-style Factors Study in Castilla y León (Spain).

Method: The Health Sentinel Network studied a sample of long-lived individuals aged 95 or more (LLI). The study included biological samples processed with the Global Screening Array v3.0 that contains a total of 730,059 markers. Written consent was obtained before the examination.

Conclusions: The LLI contacted were 944, and 760 were completed studied. The 87.4% of LLI were born in Castile and Leon and only 1% were non-native of Spain. Severe cognitive impairment was declared in 8.1% of men and 19.2% of women. Genotyping was performed in 739 LLI, the 78.3% of the contacted sample. Family doctors and nurses achieve high participation in population-based studies. DNA samples were taken from 94% of fully studied LLI, and 100% of these samples where successfully genotyped.

Keywords: Ambiente; Environment; Epidemiology; Epidemiología; Estilo de vida; Genética humana; Human genetics; Lifestyle; Longevidad; Longevity.

MeSH terms

  • Female
  • Genotype
  • Humans
  • Life Style*
  • Longevity* / genetics
  • Male
  • Spain