Vitamin A and wound healing

J Am Acad Dermatol. 1986 Oct;15(4 Pt 2):817-21. doi: 10.1016/s0190-9622(86)70238-7.


Retinoids have long been associated with wound healing, but objective data, until recently, have been scarce. Vitamin A deficiency retards repair. Secondly, retinoids restore steroid-retarded repair toward normal. Because vitamin A tends to suppress fibroblasts in cell culture and stimulate steroid-treated macrophages to initiate reparative behavior in tissue, we favor the hypothesis that retinoids are particularly important in macrophagic inflammation, which plays a central role in the control of wound healing. Probably all patients who take anti-inflammatory steroids should control their retinoid intake, but how they should control it is as yet unknown.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Interactions
  • Fibroblasts / drug effects
  • Humans
  • Retinoids / therapeutic use
  • Skin Physiological Phenomena*
  • Steroids / therapeutic use
  • Tretinoin / pharmacology
  • Vitamin A / physiology*
  • Vitamin A Deficiency / physiopathology
  • Wound Healing*


  • Retinoids
  • Steroids
  • Vitamin A
  • Tretinoin