Identifying targets to prevent aminoglycoside ototoxicity

Jinkyung Kim; Sriram Hemachandran; Alan G Cheng; Anthony J Ricci

doi:10.1016/j.mcn.2022.103722

Identifying targets to prevent aminoglycoside ototoxicity

Mol Cell Neurosci. 2022 May:120:103722. doi: 10.1016/j.mcn.2022.103722. Epub 2022 Mar 24.

Authors

Jinkyung Kim¹, Sriram Hemachandran¹, Alan G Cheng², Anthony J Ricci³

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
² Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: aglcheng@stanford.edu.
³ Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: aricci@stanford.edu.

Abstract

Aminoglycosides are potent antibiotics that are commonly prescribed worldwide. Their use carries significant risks of ototoxicity by directly causing inner ear hair cell degeneration. Despite their ototoxic side effects, there are currently no approved antidotes. Here we review recent advances in our understanding of aminoglycoside ototoxicity, mechanisms of drug transport, and promising sites for intervention to prevent ototoxicity.

Keywords: Aminoglycoside; Cochlea; Hair cell; Ototoxicity.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Aminoglycosides* / toxicity
Anti-Bacterial Agents / adverse effects
Humans
Ototoxicity*

Substances

Aminoglycosides
Anti-Bacterial Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding