Adenomyosis and infertility

J Assist Reprod Genet. 2022 May;39(5):1027-1031. doi: 10.1007/s10815-022-02476-2. Epub 2022 Mar 28.


Purpose: Adenomyosis is a poorly understood entity with no unified treatment protocol. It has been thought to only affect the quality of life of older women, but growing evidence is highlighting the increased frequency of adenomyosis in younger patients and its possible effects on fertility outcomes. This can have a great impact on how clinicians screen, diagnose, and treat this condition. The aim of this review is to explore the relationship between adenomyosis and infertility.

Methods: A literature search of the keywords "adenomyosis", "infertility", "pregnancy" and "fertility" was conducted using the PubMed and Medline search engines. The articles selected were observational, systematic reviews, meta-analyses, and randomized controlled trials. The search was limited to English, abstracts were screened, and articles were selected.

Results: The literature reports lower clinical pregnancy rates, lower live birth rates, higher miscarriage rates, and higher odds of adverse obstetric outcomes in patients with adenomyosis. Treatment seems to be associated with higher pregnancy rates and live births rates.

Conclusion: An association between adenomyosis and infertility seems to exist, and treatment could lead to improved fertility outcomes.

Keywords: Adenomyosis; Fertility; Infertility; Pregnancy.

Publication types

  • Review

MeSH terms

  • Abortion, Spontaneous* / epidemiology
  • Adenomyosis* / complications
  • Adenomyosis* / epidemiology
  • Female
  • Humans
  • Infertility, Female* / therapy
  • Live Birth
  • Pregnancy
  • Pregnancy Rate
  • Quality of Life