YAP-deLIVERing the directions and the fuel

Scott H Freeburg; Wolfram Goessling

doi:10.1016/j.devcel.2022.03.003

YAP-deLIVERing the directions and the fuel

Dev Cell. 2022 Mar 28;57(6):687-689. doi: 10.1016/j.devcel.2022.03.003.

Authors

Scott H Freeburg¹, Wolfram Goessling²

Affiliations

¹ Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA.
² Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard-MIT Division of Health Sciences and Technology, Boston, MA 02115, USA; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address: wgoessling@mgh.harvard.edu.

PMID: 35349794
DOI: 10.1016/j.devcel.2022.03.003

Abstract

Tissues and cells require fuel and cellular building blocks to respond to proliferative cues. In this issue of Developmental Cell, Vaidyanathan and colleagues modulate yes-associated protein (YAP) signaling and its downstream targets, together with phenotyping and metabolic tracing, to determine the central role of YAP in lipogenesis and associated liver growth.

Publication types

Comment

MeSH terms

Cell Proliferation
Lipogenesis*
Mechanistic Target of Rapamycin Complex 1
Sterol Regulatory Element Binding Protein 1
YAP-Signaling Proteins*

Substances

Sterol Regulatory Element Binding Protein 1
YAP-Signaling Proteins
Mechanistic Target of Rapamycin Complex 1