Local recruitment and fueling of the cellular powerplant to support cell invasion

Dev Cell. 2022 Mar 28;57(6):689-690. doi: 10.1016/j.devcel.2022.03.002.


In this issue of Developmental Cell, Garde et al. demonstrate that polarized expression of the glucose transporter FGT-1, accompanied by a localized glucose gradient and mitochondrial recruitment to the basal membrane of the anchor cell (AC), supports localized ATP generation required for basement membrane (BM) invasion in C. elegans.

Publication types

  • Comment

MeSH terms

  • Actins / metabolism
  • Adenosine Triphosphate / metabolism
  • Animals
  • Basement Membrane / metabolism
  • Caenorhabditis elegans Proteins* / metabolism
  • Caenorhabditis elegans* / metabolism
  • Cell Movement
  • Glucose / metabolism
  • Glucose Transport Proteins, Facilitative / metabolism
  • Mitochondria / metabolism


  • Actins
  • Caenorhabditis elegans Proteins
  • FGT-1 protein, C elegans
  • Glucose Transport Proteins, Facilitative
  • Adenosine Triphosphate
  • Glucose