Molecular Networking-Driven Discovery of Antibacterial Perinadines, New Tetracyclic Alkaloids from the Marine Sponge-Derived Fungus Aspergillus sp

Yang Liu; Lijian Ding; Yutong Shi; Xiaojun Yan; Bin Wu; Shan He

doi:10.1021/acsomega.2c00402

Molecular Networking-Driven Discovery of Antibacterial Perinadines, New Tetracyclic Alkaloids from the Marine Sponge-Derived Fungus Aspergillus sp

ACS Omega. 2022 Mar 8;7(11):9909-9916. doi: 10.1021/acsomega.2c00402. eCollection 2022 Mar 22.

Authors

Yang Liu¹, Lijian Ding¹, Yutong Shi¹, Xiaojun Yan¹, Bin Wu², Shan He^{1

3}

Affiliations

¹ Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315832, Zhejiang, People's Republic of China.
² Ocean College, Zhejiang University, Hangzhou 310058, People's Republic of China.
³ Ningbo Institute of Marine Medicine, Peking University, Ningbo 315800, People's Republic of China.

Abstract

Two rare tetracyclic skeleton alkaloids named perinadines B and C (1 and 2) were isolated as mixtures of epimers from the marine-derived Aspergillus sp. LS116 driven by molecular networking. The planar structures of 1 and 2 were characterized by comprehensive spectroscopic data. Additionally, compounds 1 and 2 showed moderate in vitro antibacterial activity against Bacillus subtilis with minimum inhibitory concentration values of 32 and 64 μg/mL, respectively. Besides, both of the compounds were evaluated for anti-inflammatory activities in an in vivo zebra fish model.