Statin Induced Autoimmune Necrotizing Myopathy (SIANM): An Alarming Adverse Event of a Familiar Medication

Cureus. 2022 Feb 16;14(2):e22273. doi: 10.7759/cureus.22273. eCollection 2022 Feb.


Statins are a widely prescribed medication that lowers serum cholesterol by inhibiting the HMG-CoA reductase enzyme, a rate-limiting step in cholesterol synthesis. Myopathy is one of the well-known adverse effects of statins, mainly when prescribed with the fibrates. However, statin-induced autoimmune necrotizing myopathy (SIANM) is an infrequent and severe complication. Hence, all clinicians should be more vigilant regarding this complication and treat it early to prevent acute kidney injury (AKI).

Keywords: anti-hmg co-a reductase antibodies; hypercholesterolemia; hyperlipidemia; immune-mediated necrotizing myopathy; sianm; statin-induced autoimmune necrotizing myopathy; statin-induced myopathy.

Publication types

  • Case Reports