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. 2023 Jan;25(1):11-17.
doi: 10.1080/10286020.2022.2054806. Epub 2022 Mar 29.

Schisanwilsonins H and I, two new dibenzocyclooctane lignans from the fruits of Schisandra wilsoniana

Affiliations

Schisanwilsonins H and I, two new dibenzocyclooctane lignans from the fruits of Schisandra wilsoniana

Wen-Hui Ma et al. J Asian Nat Prod Res. 2023 Jan.

Abstract

Two new dibenzocyclooctane lignans, schisanwilsonins H (1) and I (2), together with eight known compounds gomisin J (3), wulignan A1 (4), gomisin S (5), tigloylgomisin P (6), gomisin O (7), (-)-gomisin K1 (8), rubschisantherin (9) and wuweizisu C (10) were isolated from the 95% ethanol extract of the fruits of Schisandra wilsoniana. 7 exhibited anti-HBV activity with potency against HBsAg and HBeAg secretion by 37.1% and 32.6%, respectively, at 50 μg/ml. 10 exhibited anti-HIV activity with EC50 and therapeutic index (TI) values of 2.10 μg/ml and 11.98, respectively.

Keywords: Schisandra wilsoniana; Schisandraceae; dibenzocyclooctane lignan; schisanwilsonin H; schisanwilsonin I.

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