RuPHOX-Ru catalyzed asymmetric hydrogenation of α-substituted tetralones via a dynamic kinetic resolution

Jingjing Li; Jianxun Ye; Jiayu Zhou; Jing Li; Delong Liu; Wanbin Zhang

doi:10.1039/d2cc01193j

RuPHOX-Ru catalyzed asymmetric hydrogenation of α-substituted tetralones via a dynamic kinetic resolution

Chem Commun (Camb). 2022 Apr 14;58(31):4905-4908. doi: 10.1039/d2cc01193j.

Authors

Jingjing Li¹, Jianxun Ye¹, Jiayu Zhou¹, Jing Li¹, Delong Liu¹, Wanbin Zhang^{1

2}

Affiliations

¹ Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China. dlliu@sjtu.edu.cn.
² Green Catalysis Center, and College of Chemistry, Zhengzhou University, 100 Kexue Road, Zhengzhou 450001, P. R. China.

PMID: 35353102
DOI: 10.1039/d2cc01193j

Abstract

The efficient RuPHOX-Ru catalyzed asymmetric hydrogenation of α-substituted tetralones via a dynamic kinetic resolution has been achieved for the synthesis of chiral tetrahydronaphthols. The mechanism study indicated that hydrogenation with H₂ gas, rather than transfer hydrogenation with EtOH solvent as the hydrogen source, predominates in the reaction pathway.