Biochemical analysis of damage induced in yeast by formaldehyde. II. Induction of cross-links between DNA and protein

Mutat Res. 1978 Jul;51(1):11-9. doi: 10.1016/0027-5107(78)90003-9.


Exposure of Saccharomyces cerevisiae cells to formaldehyde-induced cross-links between DNA and proteins. This damage was demonstrated by three different techniques. Ultraviolet irradiation also produced cross-links between DNA and proteins in yeast.

MeSH terms

  • Centrifugation, Density Gradient
  • DNA / metabolism*
  • Dose-Response Relationship, Drug
  • Formaldehyde / pharmacology*
  • Fungal Proteins / metabolism*
  • Saccharomyces cerevisiae / drug effects
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / radiation effects
  • Ultraviolet Rays


  • Fungal Proteins
  • Formaldehyde
  • DNA