Pompholyx as a side effect of intravenous immunoglobulin (IVIg)

BMJ Case Rep. 2022 Mar 30;15(3):e248772. doi: 10.1136/bcr-2022-248772.


Intravenous immunoglobulin (IVIg) is increasingly used across multiple specialties for the treatment of inflammatory and autoimmune diseases. Cutaneous reactions to IVIg are generally minor. Pompholyx is a common eruption of small vesicles on the palms, soles, and/or lateral aspects of the fingers. It has a multifactorial aetiology but is rarely attributed to being a drug-related side effect. We describe a 43-year-old woman presenting with peripheral sensory neuropathy who developed pompholyx eczema on both palms following treatment with IVIg.

Keywords: Dermatology; Drugs and medicines; Skin.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Autoimmune Diseases* / drug therapy
  • Drug-Related Side Effects and Adverse Reactions*
  • Eczema, Dyshidrotic* / chemically induced
  • Eczema, Dyshidrotic* / drug therapy
  • Female
  • Humans
  • Immunoglobulins, Intravenous / adverse effects
  • Peripheral Nervous System Diseases* / chemically induced


  • Immunoglobulins, Intravenous