Abstract
Deposition of amyloid is the most constantly present alteration in the islets of Langerhans in type 2 diabetes mellitus and is also quite common in insulin-producing tumors of the pancreas and it is very likely that these two amyloids are identical. We have isolated amyloid fibrils from an insulin-secreting human tumour and purified the fibrillar protein. N-terminal amino acid sequence of the protein is unique and does not resemble insulin or its precursors. Instead it has about 50% homology with the neuropeptide CGRP (calcitonin gene related peptide).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Amyloid / genetics
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Amyloid / isolation & purification*
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Calcitonin Gene-Related Peptide
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Chromatography, High Pressure Liquid
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Humans
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Insulin / metabolism
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Insulin Secretion
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Islets of Langerhans / analysis*
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Male
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Middle Aged
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Neoplasm Proteins / genetics
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Neoplasm Proteins / isolation & purification
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Neuropeptides / genetics
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Pancreatic Neoplasms / analysis
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Pancreatic Neoplasms / metabolism
Substances
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Amyloid
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Insulin
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Neoplasm Proteins
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Neuropeptides
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Calcitonin Gene-Related Peptide