On 'Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes?' by Graham W. Burton, Anne Joyce, Keith U. Ingold

G W Burton; A Joyce; K U Ingold

doi:10.1016/j.abb.2022.109195

On 'Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes?' by Graham W. Burton, Anne Joyce, Keith U. Ingold

Arch Biochem Biophys. 2022 Sep 15:726:109195. doi: 10.1016/j.abb.2022.109195. Epub 2022 Mar 28.

Authors

G W Burton¹, A Joyce², K U Ingold²

Affiliations

¹ Avivagen Inc., Ottawa, ON, Canada. Electronic address: g.burton@avivagen.com.
² Avivagen Inc., Ottawa, ON, Canada.

PMID: 35358488
DOI: 10.1016/j.abb.2022.109195

Abstract

Application of a time-tested quantitative method of measuring peroxyl radical production in conjunction with the determination of the stoichiometry of the reaction of peroxyl radicals with α-tocopherol has permitted the conclusion that α-tocopherol is the major lipid-soluble chain-breaking antioxidant in human plasma and red cell membranes.

MeSH terms

Antioxidants* / metabolism
Erythrocyte Membrane / metabolism
Free Radicals / metabolism
Humans
Lipid Peroxidation
Lipids
Plasma
Vitamin E*
alpha-Tocopherol

Substances

Antioxidants
Free Radicals
Lipids
Vitamin E
alpha-Tocopherol