A randomized, double-blind trial comparing a pulse of 1000 with 250 mg methylprednisolone in rheumatoid arthritis

Clin Rheumatol. 1986 Sep;5(3):325-6. doi: 10.1007/BF02054249.


We compared, in a double blind, randomized, 3-center study, a pulse of 1000 mg methylprednisolone with a pulse of 250 mg methylprednisolone, in patients with active rheumatoid arthritis. Improvement of patients was similar in both groups and lasted up to 3 weeks. Side effects were minor.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthritis, Rheumatoid / drug therapy*
  • Clinical Trials as Topic
  • Double-Blind Method
  • Humans
  • Methylprednisolone / administration & dosage*
  • Random Allocation


  • Methylprednisolone