Locally produced autoantibodies in cancer

Cell. 2022 Mar 31;185(7):1110-1111. doi: 10.1016/j.cell.2022.03.006.


The function and antigen-specificities of tumor-infiltrating B cells are mostly unknown. In a new study by Mazor et al., matrix metalloproteinase 14 (MMP14), a self-antigen that is overexpressed by ovarian cancers, is shown to drive B cell activation and autoantibody production in tertiary lymphoid structures (Mazor et al., 2022).

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Autoantibodies*
  • Autoantigens
  • B-Lymphocytes
  • Female
  • Humans
  • Ovarian Neoplasms*


  • Autoantibodies
  • Autoantigens