Association of respiratory symptoms with body mass index and occupational exposure comparing sexes and subjects with and without asthma: follow-up of a Norwegian population study (the Telemark study)

Geir Klepaker; Paul Keefer Henneberger; Kjell Torén; Cathrine Brunborg; Johny Kongerud; Anne Kristin Møller Fell

doi:10.1136/bmjresp-2021-001186

Association of respiratory symptoms with body mass index and occupational exposure comparing sexes and subjects with and without asthma: follow-up of a Norwegian population study (the Telemark study)

BMJ Open Respir Res. 2022 Mar;9(1):e001186. doi: 10.1136/bmjresp-2021-001186.

Authors

Geir Klepaker^{1

2}, Paul Keefer Henneberger³, Kjell Torén⁴, Cathrine Brunborg⁵, Johny Kongerud^{6

7}, Anne Kristin Møller Fell^{8

9}

Affiliations

¹ Department of Occupational and Environmental Medicine, Telemark Hospital, Skien, Norway geir.klepaker@sthf.no.
² Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
³ Respiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA.
⁴ Department of Occupational and Environmental Medicine, University of Gothenburg, Gothenburg, Sweden.
⁵ Oslo Centre for Biostatistics, Epidemiology and Health Economics, Oslo University Hospital, Oslo, Norway.
⁶ Department of Respiratory Medicine, University of Oslo, Oslo, Norway.
⁷ Department of Respiratory Medicine, Oslo University Hospital, Oslo, Norway.
⁸ Department of Occupational and Environmental Medicine, Telemark Hospital, Skien, Norway.
⁹ Institute of Health and Society, Department of Community Medicine and Global Health, University of Oslo Faculty of Medicine, Oslo, Norway.

Abstract

Background: Occupational exposure and increased body mass index (BMI) are associated with respiratory symptoms. This study investigated whether the association of a respiratory burden score with changes in BMI as well as changes in occupational exposure to vapours, gas, dust and fumes (VGDF) varied in subjects with and without asthma and in both sexes over a 5-year period.

Methods: In a 5-year follow-up of a population-based study, 6350 subjects completed a postal questionnaire in 2013 and 2018. A respiratory burden score based on self-reported respiratory symptoms, BMI and frequency of occupational exposure to VGDF were calculated at both times. The association between change in respiratory burden score and change in BMI or VGDF exposure was assessed using stratified regression models.

Results: Changes in respiratory burden score and BMI were associated with a β-coefficient of 0.05 (95% CI 0.04 to 0.07). This association did not vary significantly by sex, with 0.05 (0.03 to 0.07) for women and 0.06 (0.04 to 0.09) for men. The association was stronger among those with asthma (0.12; 0.06 to 0.18) compared with those without asthma (0.05; 0.03 to 0.06) (p=0.011). The association of change in respiratory burden score with change in VGDF exposure gave a β-coefficient of 0.15 (0.05 to 0.19). This association was somewhat greater for men versus women, with coefficients of 0.18 (0.12 to 0.24) and 0.13 (0.07 to 0.19), respectively (p=0.064). The estimate was similar among subjects with asthma (0.18; -0.02 to 0.38) and those without asthma (0.15; 0.11 to 0.19).

Conclusions: Increased BMI and exposure to VGDF were associated with increased respiratory burden scores. The change due to increased BMI was not affected by sex, but subjects with asthma had a significantly larger change than those without. Increased frequency of VGDF exposure was associated with increased respiratory burden score but without statistically significant differences with respect to sex or asthma status.

Keywords: Asthma; Asthma Epidemiology; Clinical Epidemiology; Occupational Lung Disease; Perception of Asthma/Breathlessness.

MeSH terms

Asthma* / epidemiology
Body Mass Index
Dust
Female
Follow-Up Studies
Humans
Male
Occupational Exposure* / adverse effects

Substances

Dust