Abnormally large placenta associated with Beckwith-Wiedemann syndrome

Gynecol Obstet Invest. 1986;22(3):165-8. doi: 10.1159/000298909.


A 37-year-old G1-P1 was diagnosed by ultrasonography at 26 weeks of gestation as having an abnormally large placenta with hemangiomas and a fetus associated with exomphalos. Placental protein 5 levels were relatively high in placental protein levels in maternal serum. The infant, delivered by cesarean section at 34 weeks, had the typical clinical features associated with Beckwith-Wiedemann syndrome. The abnormally large placenta weighed 1,492 g, measured 25 X 25 X 5.1 cm, and featured multiple hemangiomas. Microscopic placental features included edematous villi, increased fibrin deposition, intervillous thrombi, and multiple angiomatous and cellular chorangiomas.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Beckwith-Wiedemann Syndrome / pathology*
  • Female
  • Hemangioma / blood
  • Hemangioma / pathology
  • Humans
  • Infant, Newborn
  • Infant, Premature, Diseases / pathology*
  • Maternal Age
  • Placenta / pathology*
  • Placenta Diseases / pathology
  • Pregnancy
  • Pregnancy Proteins / blood
  • Pregnancy, High-Risk
  • Ultrasonography


  • Pregnancy Proteins