A Five-Year Review of the Outcomes of Breast Imaging Reporting and Data System 4 Lesions in Hospital Universiti Sains Malaysia

Karthikeyan Marthay; Maya Mazuwin Yahya; Tengku Ahmad Damitri Al-Astani Tengku Din; Wan Zainira Wan Zain; Juhara Haron; Michael Pak-Kai Wong; Rosenelifaizur Ramely; Wan Muhammad Mokhzani Wan Mokhter; Siti Rahmah Hashim Isa Merican; Mohd Nizam Mohd Hashim

doi:10.7759/cureus.22757

A Five-Year Review of the Outcomes of Breast Imaging Reporting and Data System 4 Lesions in Hospital Universiti Sains Malaysia

Cureus. 2022 Mar 1;14(3):e22757. doi: 10.7759/cureus.22757. eCollection 2022 Mar.

Affiliations

¹ Department of Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MYS.
² Breast Cancer Research and Awareness Unit (BestARi), Hospital Universiti Sains Malaysia, Kota Bharu, MYS.
³ Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MYS.
⁴ Breast Cancer Awareness and Research Unit (BestARi), Hospital Universiti Sains Malaysia, Kota Bharu, MYS.
⁵ Department of Radiology, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MYS.

Abstract

Purpose: The Breast Imaging Reporting and Data System (BI-RADS) lexicon used in reporting breast imaging has several categories with specific positive predictive values for breast cancer. Among those, BI-RADS 4 is associated with a wider range of risk for breast cancer, which makes the decision for biopsy difficult. The study aim was to determine the malignancy rate and clinical outcomes of BI-RADS 4 lesions in Hospital Universiti Sains Malaysia (HUSM) for a period of five years.

Methods: This was a retrospective study of patients diagnosed by mammographic or ultrasonographic findings with BI-RADS 4 breast lesions in HUSM, Kelantan from July 2015 to June 2020. Data were collected from the medical records and an electronic database. Patients with BI-RADS 4 lesions who underwent biopsy and had a known tissue diagnosis were included in this study. The data was used to calculate the malignancy rate and associated positive predictive factors for breast cancer associated with BI-RADS 4 lesions.

Results: From the mammography and ultrasonography performed at HUSM from July 2015 to June 2020, a total of 256 lesions were categorized as BI-RADS 4. However, only 198 BI-RADS 4 lesions underwent biopsy and were included in the study. Of these 198 lesions, 26.8% were malignant on histopathological examination of the biopsy samples. Simple logistic regression analysis showed that age, diabetes mellitus, hypertension, number of parity, and certain mammogram findings were significantly associated with breast cancer. Invasive breast cancer was the most common type. Fibrocystic disease was the most common benign pathology, followed by fibroadenoma.

Conclusion: The malignancy rate of BI-RADS 4 lesions in HUSM was similar to previously reported rates. A thorough evaluation of positive predictive factors and careful selection of patients for biopsy in BI-RADS 4 lesions will minimize unwanted biopsies and associated patient anxiety, in addition to reducing the health care burden.

Keywords: bi-rads4; biopsy; breast carcinoma; breast ultrasonography; mammography.