Vive la Résistance: T-cell Immunity in the Protection against SARS-CoV-2 Infection

Cancer Discov. 2022 Apr 1;12(4):892-894. doi: 10.1158/2159-8290.CD-22-0080.

Abstract

Fahrner and colleagues investigated the immune response of patients with cancer and cancer-free individuals to SARS-CoV-2 and found that a propensity toward an IL5-predominant Th2/Tc2 response was predictive of susceptibility to infection. The results of this study also suggest that a cellular response against the Spike 1 protein receptor binding domain (S1-RBD) region of the SARS-CoV-2 proteome contributes to protection and that mutations in this region may drive viral evolution and immune escape. See related article by Fahrner et al., p. 958 (8).

Publication types

  • Editorial
  • Comment

MeSH terms

  • COVID-19* / genetics
  • Humans
  • Membrane Glycoproteins / genetics
  • SARS-CoV-2
  • Spike Glycoprotein, Coronavirus / genetics
  • T-Lymphocytes / metabolism
  • Viral Envelope Proteins / genetics
  • Viral Envelope Proteins / immunology
  • Viral Envelope Proteins / metabolism

Substances

  • Membrane Glycoproteins
  • Spike Glycoprotein, Coronavirus
  • Viral Envelope Proteins
  • spike protein, SARS-CoV-2