The aim of this retrospective study was to evaluate the long-term predictability of treatment using implants with hydrophobic and hydrophilic surfaces, according to clinical parameters and survival rates. Records from all patients who received dental implants between January 2013 and December 2014 at ILAPEO College were fully evaluated by two graduate dentists. Records with incomplete or unclear data were excluded from the study. The variables evaluated were demographic data, design of implants and prosthetic components, type of loading, data related to the patients' general health, and survival of implants and prostheses. The final retrospective sample comprised 776 patients with 2707 implants, with up to 5 years of follow-up. Survival rates of implants and prostheses were 97.93% and 98.77%, respectively. Implants with hydrophobic (97.87%) and hydrophilic (98.34%) surfaces exhibited similar survival rates. Considering the different types of loading, there was no statistically significant difference between loading protocols regarding implant survival rates. Unsuitable healing capacity, uncooperative and not motivated patient, loss of prosthesis, and peri-implant bone loss were confirmed statistically to be factors that may contribute to implant loss, according to hazard ratio and odds ratio. The present study showed similar and high overall survival rates for implant with both types of surfaces, in the long term. The surface treatment, implant model and loading protocol had no significant influence on implant loss. Therefore, the evaluated implant systems were able to offer a high predictability for both hydrophobic and hydrophilic implants.