LncRNA: a new perspective on the study of neurological diseases

Yun Ma; Siqi He; Tianhe Gu; Yixuan Liu; Shuya He; Zhisheng Jiang

doi:10.1042/BST20211181

LncRNA: a new perspective on the study of neurological diseases

Biochem Soc Trans. 2022 Apr 29;50(2):951-963. doi: 10.1042/BST20211181.

Authors

Yun Ma^{1

2

3

4}, Siqi He¹, Tianhe Gu¹, Yixuan Liu¹, Shuya He^{1

4}, Zhisheng Jiang^{1

2}

Affiliations

¹ Institute of Biochemistry and Molecular Biology, Hengyang Medical School, University of South China, Hengyang 421 001, China.
² Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang Medical School, University of South China, Hengyang 421 001, China.
³ Key Laboratory of Ecological Environment and Critical Human Diseases Prevention of Hunan Province Department of Education, Hengyang Medical School, University of South China, Hengyang 421 001, China.
⁴ Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical School, University of South China, Hengyang 421 001, China.

PMID: 35383841
DOI: 10.1042/BST20211181

Abstract

Long non-coding RNAs (lncRNAs) are a class of non-coding RNA with a length greater than 200 nt. It has a mRNA-like structure, formed by splicing after transcription, and contains a polyA tail and a promoter, of whom promoter plays a role by binding transcription factors. LncRNAs' sequences are low in conservation, and other species can only find a handful of the same lncRNAs as humans, and there are different splicing ways during the differentiation of identical species, with spatiotemporal expression specificity. With developing high-throughput sequencing and bioinformatics, found that more and more lncRNAs associated with nervous system disease. This article deals with the regulation of certain lncRNAs in the nervous system disease, by mean of to understand its mechanism of action, and the pathogenesis of some neurological diseases have a fresh understanding, deposit a foundation for resulting research and clinical treatment of disease.

Keywords: Diseases of the nervous system; ceRNA; lncrna; microRNA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Computational Biology / methods
Gene Regulatory Networks
Humans
MicroRNAs* / metabolism
Nervous System Diseases* / genetics
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism
RNA, Messenger / metabolism

Substances

MicroRNAs
RNA, Long Noncoding
RNA, Messenger