Cancer stem cells: The adventurous journey from hematopoietic to leukemic stem cells

Andreas Trumpp; Simon Haas

doi:10.1016/j.cell.2022.03.025

Cancer stem cells: The adventurous journey from hematopoietic to leukemic stem cells

Cell. 2022 Apr 14;185(8):1266-1270. doi: 10.1016/j.cell.2022.03.025. Epub 2022 Apr 5.

Authors

Andreas Trumpp¹, Simon Haas²

Affiliations

¹ Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address: a.trumpp@dkfz.de.
² Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, 10117 Berlin, Germany; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), 10115 Berlin, Germany; Department of Hematology, Oncology and Cancer Immunology, Charité - Universitätsmedizin Berlin, 10115 Berlin, Germany.

PMID: 35385684
DOI: 10.1016/j.cell.2022.03.025

Abstract

This year's Gairdner Foundation Award for Biomedical Research is awarded to John Dick for the discovery of leukemic stem cells and the hierarchical organization of acute myeloid leukemias. His work laid the foundation for the cancer stem cell model with numerous clinical implications for hematopoietic malignancies and solid tumors.

MeSH terms

Awards and Prizes*
Biomedical Research*
Humans
Leukemia, Myeloid, Acute* / pathology
Neoplastic Stem Cells* / pathology