Making a sPLAsh: The expanding repertoire of EV signaling

Cell Metab. 2022 Apr 5;34(4):508-510. doi: 10.1016/j.cmet.2022.03.004.


Extracellular vesicles (EVs) and their cargo act as signaling moieties by transferring their cargo to recipient cells, thereby mediating intercellular communication in complex tissue environments such as the tumor microenvironment. In the accompanying paper, Kudo et al. describe the interaction between tumor EVs and soluble phospholipase released by macrophages, leading to the remodeling of EV membranes and the release of lipid mediators that facilitate tumor growth by inducing an immune-tolerant phenotype.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Cell Communication
  • Extracellular Vesicles*
  • Humans
  • Neoplasms* / pathology
  • Signal Transduction
  • Tumor Microenvironment