Back-to-BACs in Huntington's disease modeling

Neuron. 2022 Apr 6;110(7):1087-1089. doi: 10.1016/j.neuron.2022.02.022.


In this issue of Neuron, Gu et al. (2022) describe a new BAC mouse model that faithfully recapitulates various aspects of Huntington's disease pathobiology and reveals important insights into the relative toxicities of mHTT-derived products.

Publication types

  • Comment

MeSH terms

  • Animals
  • Disease Models, Animal
  • Huntingtin Protein / genetics
  • Huntington Disease* / genetics
  • Mice
  • Neurons / physiology


  • Huntingtin Protein