Longitudinal optical coherence tomography angiography (OCT-A) in a patient with radiation retinopathy following plaque brachytherapy for uveal melanoma

Elaine M Binkley; Michelle R Tamplin; Anthony H Vitale; H Culver Boldt; Randy H Kardon; Isabella M Grumbach

doi:10.1016/j.ajoc.2022.101508

Longitudinal optical coherence tomography angiography (OCT-A) in a patient with radiation retinopathy following plaque brachytherapy for uveal melanoma

Am J Ophthalmol Case Rep. 2022 Mar 25:26:101508. doi: 10.1016/j.ajoc.2022.101508. eCollection 2022 Jun.

Authors

Elaine M Binkley¹, Michelle R Tamplin², Anthony H Vitale³, H Culver Boldt¹, Randy H Kardon^{1

4}, Isabella M Grumbach^{2

3

4}

Affiliations

¹ Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA.
² Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA, USA.
³ Abboud Cardiovascular Research Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
⁴ Iowa City VA Center for the Prevention and Treatment of Visual Loss, Iowa City, IA, USA.

Abstract

Purpose: Patients with choroidal melanoma treated with brachytherapy lose vision over time due to radiation retinopathy and optic neuropathy. Newer imaging modalities such as optical coherence tomography angiography (OCT-A) may provide further insight into the ultrastructural vascular changes that occur over time. We studied the progressive OCT-A derived reduction in capillary density that occurred in the macula and juxtapapillary region of a patient treated with plaque brachytherapy for posterior uveal melanoma.

Methods: A patient with medium-sized choroidal melanoma in the inferonasal mid-periphery of the right eye was followed with OCT-A imaging in addition to standard imaging (color fundus photography, standardized echography, OCT) over a four-year time period following brachytherapy. Images were analyzed to measure vascular density in nine discrete areas of the macula at each time point as a function of region-specific radiation dose.

Results: OCT-A over time showed focal capillary loss and enlargement of the foveal avascular zone in addition to vascular re-modeling. These changes progressed over time despite improvement in the clinical markers of radiation retinopathy (cotton wool spots, retinal hemorrhages). Radiation dose significantly correlated with rate of reduction in vascular density assessed within 9 square sectors of the macula, and was greatest in sectors closest to the plaque, which had received the highest radiation dose. There was no change in the choriocapillaris flow area over time. The patient developed cystoid macular edema, but maintained 20/30 vision.

Conclusions and importance: Longitudinal OCT-A demonstrates the microvascular changes that occur in response to radiation over time. Identification of these features may help define therapeutic windows to prevent vision loss associated with radiation retinopathy and optic neuropathy. Ongoing studies will describe a larger cohort of patients followed with this modality over time.

Keywords: Optical coherence tomography angiography; Radiation retinopathy; Uveal melanoma.

Abstract

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