Dnmt3a-Mutant Hematopoietic Stem Cell Rewire IFNγ Signaling to Gain Clonal Advantage

Marco De Dominici; James DeGregori

doi:10.1158/2643-3230.BCD-22-0025

Dnmt3a-Mutant Hematopoietic Stem Cell Rewire IFNγ Signaling to Gain Clonal Advantage

Blood Cancer Discov. 2022 May 5;3(3):178-180. doi: 10.1158/2643-3230.BCD-22-0025.

Authors

Marco De Dominici, James DeGregori¹

Affiliation

¹ Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Abstract

Dnmt3a-mutant stem cells gain a competitive advantage via upregulation of a Txnip-p53-p21 axis and protection from IFNγ induced exhaustion. See related article by Zhang et al., p. 220 (5).

Publication types

Editorial
Research Support, N.I.H., Extramural
Comment

MeSH terms

Cells, Cultured
DNA (Cytosine-5-)-Methyltransferases* / genetics
DNA Methyltransferase 3A*
DNA Modification Methylases
Hematopoietic Stem Cells

Substances

DNA Modification Methylases
DNA (Cytosine-5-)-Methyltransferases
DNA Methyltransferase 3A